The directed differentiation of human pluripotent stem cells (hPSC) towards the hematopoietic lineages would be an invaluable tool for regenerative medicine, providing cells for both transplantation and in vitro analysis. As the PSC system has been shown to recapitulate developmental events in vitro, it is also a powerful model system for developmental biology, being the only method to-date that allows interrogation of the cellular and molecular mechanisms that regulate human development. Furthermore, the recent technological advancement to generate induced pluripotent stem cells offers the potential to model not only development, but also disease in a dish.
Understanding human primitive and definitive hematopoietic development; understanding the endothelial-to-hematopoietic transition in hemogenic endothelium, ultimately giving rise to an HSC; and modeling hematopoietic disease with iPSC
We're currently a group of five resident scientists—Christopher Sturgeon, PhD, our lab manager, two postdoctoral fellows, and one doctoral student.
Our work has been published in many high-impact peer-reviewed journals, including Nature Cell Biology, Nature Reviews Molecular Cell Biology, Blood, Nature Biotechnology, Developmental Cell, and Stem Cell Reports.